Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas
نویسندگان
چکیده
منابع مشابه
Endonasal endoscopic removal of growth-hormone-secreting pituitary adenomas.
Trans-sphenoidal removal of pituitary tumours using the endonasal endoscopic technique, a novel application, is herein reported in five consecutive patients with growth-hormone-secreting pituitary adenomas seen at a teaching hospital in Hong Kong. All five patients demonstrated complete tumour removal on postoperative imaging and hormonal assessment following the procedure. Surgical morbidity a...
متن کاملDifferential expression of microRNAs in GH-secreting pituitary adenomas
BACKGROUND The purpose of this study was to (1) identify specific miRNAs in growth hormones (GH)-secreting pituitary adenomas; (2) determine the relationship between the expression of these miRNAs and tumor size, somatostatin analogs treatment, and responsiveness to somatostatin analogs (SSA). METHODS Fifteen GH-secreting adenomas patients were treated with lanreotide for 4 months before surg...
متن کاملExpression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
CONTEXT Seladin-1 (from selective Alzheimer's disease indicator-1) is a recently discovered gene that has been found to be down-regulated in brain regions affected by Alzheimer's disease. Seladin-1 effectively protects neurons against beta-amyloid-mediated toxicity and prevents apoptosis via inhibition of the activation of caspase-3, a key mediator of the apoptotic cascade. Although seladin-1 i...
متن کاملProlactin Secreting Pituitary Adenomas
Correspondence to: Ioana Muntean, e-mail: [email protected] ABSTRACT. Hyperprolactinemia has different etiologic forms, among them, the prolactin-secreting pituitary tumors represent an important entity. In our study, were analyzed the clinical aspects, diagnostic procedures and therapeutical approach of 31 cases of prolactinomas (F/M ratio = 27/4) hospitalized in the Clinic of Endocrinol...
متن کاملEctopic Adrenocorticotropic Hormone-Secreting Pituitary Adenomas: An Underestimated Entity.
BACKGROUND The diagnosis of Cushing disease is based on endocrinological pa-rameters, with no single test being specific. In some patients, dynamic thin-slice sellar magnetic resonance imaging fails to detect a pituitary tumor. OBJECTIVE The purpose of this study is to investigate the role of ectopic pituitary adenoma in this situation. METHODS In a retrospective chart review, 5 patients (6...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2010
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2010.137